Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
نویسندگان
چکیده
This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.
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ورودعنوان ژورنال:
- Journal of Alzheimer's disease : JAD
دوره 28 2 شماره
صفحات -
تاریخ انتشار 2012